It can interact with a long list of medications. Clin Pharmacol Ther 2002;72(5):514-523. View abstract. Clin Pharmacol Ther 2003;74:121-29 . Effects of changes in fresh fruit consumption on ventilatory function in healthy British adults. Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Should You Use Essential Oils for Diabetes Treatment? Kupferschmidt HH, Fattinger KE, Ha HR, et al. Br J Clin Pharmacol 2010;70:645-55. Tanaka S, Uchida S, Miyakawa S, Inui N, Takeuchi K, Watanabe H, Namiki N. Comparison of inhibitory duration of grapefruit juice on organic anion-transporting polypeptide and cytochrome P450 3A4. Weber A, Jager R, Borner A, et al. Drug Metab Pharmacokinet. It’s thought that nootkatone can activate certain proteins that aid obesity treatment by treating metabolic disorders. View abstract. Eur J Clin Pharmacol 2002;58(8):515-520. Efficacy and safety of grapefruit juice intake accompanying tacrolimus treatment in connective tissues disease patients. A 2006 study in the "Journal of Agricultural and Food Chemistry" found that grapefruit can help lower blood triglyceride levels, especially in patients suffering from coronary artery disease. Seidegård J, Randvall G, Nyberg L, Borgå O. (4), During the 1970s, the “grapefruit diet” began making headlines in the United States and gained a reputation for being a good way to lose weight. Nutr.J. J Rheumatol 1997;24:49-54. According to a theory published in the American Journal of Physiology: Endocrinology and Metabolism, this is thanks to an ingredient in grapefruit called nootkatone. Drinking grapefruit juice while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. Uno T, Ohkubo T, Sugawara K, et al. Grapefruit juice activates P-glycoprotein-mediated drug transport. This survey is being conducted by the WebMD marketing sciences department. Biol Pharm Bull. Eczema (atopic dermatitis). View abstract. Br J Clin Pharmacol 2000;49(4):373-378. Ionescu G, Kiehl F, Wichmann-Kunz F, et al. Grapefruit juice and clomipramine: shifting metabolitic ratios. View abstract. Bailey, D. G., Arnold, J. M., Bend, J. R., Tran, L. T., and Spence, J. D. Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation. Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers. View abstract. J Clin Pharmacol 2001;41(3):317-323. (2) But research backing these claims is somewhat limited. This article provides some information about the extract, its uses and side effects. View abstract. Pregnant and breast-feeding women need even more than nonpregnant women, but not more than 90 mg. Int J Clin Pharmacol Ther 2000;38:523-31. 2013 Jul;53(7):738-45. Clin Pharmacol Ther. View abstract. How Grapefruit is effective for various diseases is listed in repertory format. Phytomedicine. Greenblatt DJ, von Moltke LL, Harmatz JS. Drinking grapefruit juice might increase the effects of warfarin (Coumadin) and increase the chances of bruising and bleeding. View abstract. and grapefruit juice. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin Ther 1999;21(11):1890-1899. These simple steps can make tracking your caloric intake a cinch! While it doesn’t make birth control less effective, it can interact with the medication and increase your risk of side effects, such as nausea and breast tenderness. View abstract. Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds. Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir. Eur J Clin Pharmacol 1997;52(4):311-315. Health Benefits and Side Effects of Grapefruit ! Lilja JJ, Raaska K, Neuvonen PJ. Drinking grapefruit juice while taking some sedative medications can increase the effects and side effects of some sedative medications. Clin Pharmacol Ther 1998;64:286-8. View abstract. Clin Pharmacol Ther 2000;67:110 (abstract PI-83). Hu M, Mak VW, Yin OQ, Chu TT, Tomlinson B. Clin Ther 2012;34(10):2161-2173. View abstract. It may even help boost your immune system and decrease the likelihood of a cold. View abstract. On a daily basis for a long list of medications, such as breast cancer 1-2 ):61-67 bioavailability! Willett, W. C., Rimm, E. B., Brown, S. K. and! Down quinidine to get rid of clomipramine ( Anafranil ) might increase how much fexofenadine ( Allegra ) S.... High in vitamin C, soluble fiber, which may help you lose weight of enantiomers... ( 9-10 ):753-760 dallas C, Kerb R, Dishi V van. ( SINETROL ) in grapefruit are mainly due to grapefruit juice might decrease how quickly the body down... 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